Effective analgesic doses of tramadol or tapentadol induce brain, lung and heart toxicity in Wistar rats.

Bibliographic reference: 

Faria J., Barbosa J., Leal S., Afonso LP., Lobo J., Moreira R., Queirós O., Carvalho F., & Dinis-Oliveira RJ. (2017). Effective analgesic doses of tramadol or tapentadol induce brain, lung and heart toxicity in Wistar rats. Toxicology. Jun 15; 385:38-47.

Bibliographic link: 
https://dx.doi.org/10.1016/j.tox.2017.05.003