Cancers have been the leading cause of death worldwide and there are any extremely effective and safe drugs to treat most of the cancers. Due to an increase demand for new anticancer agents, efficient, specific and less toxic; natural products offer opportunities for innovation in drug discovery. In fact, natural products play a major role in cancer prevention and treatment. A considerable number of antitumor agents currently used in the clinic are of natural origin. Among natural products, medicinal plants and specially aromatics and their essential oils (EO), composed of hundreds of lipophilic and low molecular compounds, represents an interesting source of new antitumor compounds. Recent studies have evaluated some EO globally for their anticancer activity however many EO and main terpenoids are yet to be study and characterized on their anticancer activity. Thus, this work will provide information about the potential effects of new compounds/extracts and their combination with commercial chemotherapeutic drugs.