Faced with the increasing lack of activity by antimicrobial agents, novel avenues of research need to be explored. In this project, we propose to test several synthetic compounds and natural plant extracts to see if they have the potential to inhibit some characteristics that augment the virulence of 3 common bacterial pathogens (Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa) and one fungal pathogen (Candida albicans). The compounds and extracts will be tested for their ability to hinder the formation of biofilm or to disrupt mature biofilm by the 4 species, or to inhibit the biosynthesis of pigments important for the virulent behaviour of S. aureus and P. aeruginosa. If any of these compounds shows any such ability, it may in the future be used as an adjuvant antimicrobial as it may lessen the virulence burden of the pathogen on the host and increase the chances of therapy to be successful and of the host’s immune system to counteract the infection.