The One Health Toxicology Research Unit (1H-TOXRUN) aims to be national leader in the field of toxicology research.
Based on our backgrounds as a researchers and academics, the state of the art of our scientific field, the feasibility of which realistically can be reachable, some optimism and ambition, the establishment of collaborations, the regional and national impact, the international relevance of research results, TOXRUN is focused:
1. To understand, from a multidisciplinary and integrative perspective, in in vitro models, in animals and in patients, the metabolism and metabolomics of licit and illicit opioids and their implications for the pathophysiology of diseases.
2. To develop antidotes for intoxications.
3. To understand the pathophysiological mechanisms at the base of paraquat-induced pulmonary toxicity.
4. To understand the clinical and forensic signs of xenobiotic exposure.
5. To study the different biomarkers of toxicity in different pathologies.
6. To study pharmacogenomics and pharmacogenetics and their importance in understanding the variability of dose response.
7. To study the signaling mechanisms that lead to apoptosis and necrosis.
8. To develop in vitro and in vivo studies related to the use of new inducers of the de novo synthesis of P-glycoprotein.
9. To study food toxicology and create scientific background in this area.
10. To develop analytical methods for screening and confirming poisoning, including using alternative samples such as hair.
11. To study the target toxicity organs of different xenobiotics.
12. To continue to belong to the editorial bodies of different scientific journals in Health and Life Sciences.
13. To guide students from different Cycles of Studies, promote activities of extension, dissemination, and economic and social valorization of knowledge, stimulating the culture of good scientific practices.
Coordinator
Ricardo Dinis-Oliveira
Overview
The One Health Toxicology Research Unit (1H-TOXRUN) aims to be national leader in the field of toxicology research.
Based on our backgrounds as a researchers and academics, the state of the art of our scientific field, the feasibility of which realistically can be reachable, some optimism and ambition, the establishment of collaborations, the regional and national impact, the international relevance of research results, TOXRUN is focused:
1. To understand, from a multidisciplinary and integrative perspective, in in vitro models, in animals and in patients, the metabolism and metabolomics of licit and illicit opioids and their implications for the pathophysiology of diseases.
2. To develop antidotes for intoxications.
3. To understand the pathophysiological mechanisms at the base of paraquat-induced pulmonary toxicity.
4. To understand the clinical and forensic signs of xenobiotic exposure.
5. To study the different biomarkers of toxicity in different pathologies.
6. To study pharmacogenomics and pharmacogenetics and their importance in understanding the variability of dose response.
7. To study the signaling mechanisms that lead to apoptosis and necrosis.
8. To develop in vitro and in vivo studies related to the use of new inducers of the de novo synthesis of P-glycoprotein.
9. To study food toxicology and create scientific background in this area.
10. To develop analytical methods for screening and confirming poisoning, including using alternative samples such as hair.
11. To study the target toxicity organs of different xenobiotics.
12. To continue to belong to the editorial bodies of different scientific journals in Health and Life Sciences.
13. To guide students from different Cycles of Studies, promote activities of extension, dissemination, and economic and social valorization of knowledge, stimulating the culture of good scientific practices.